Flavio Leoni Selected Research

givinostat hydrochloride

1/2019	Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma.
1/2019	Correction to: Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma.
5/2011	Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis.
1/2005	The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.

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Flavio Leoni Research Topics

Disease

5	Neoplasms (Cancer) 12/2019 - 03/2002
3	Inflammation (Inflammations) 05/2011 - 01/2005
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021 - 05/2013
2	Glioblastoma (Glioblastoma Multiforme) 01/2019 - 01/2019
2	Arthritis (Polyarthritis) 05/2011 - 03/2002
2	Experimental Arthritis 05/2011 - 03/2002
1	Fibrosis (Cirrhosis) 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 12/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2019
1	Psoriasis (Pustulosis Palmaris et Plantaris) 08/2014
1	Cicatrix (Scar) 05/2013
1	Muscular Dystrophies (Muscular Dystrophy) 05/2013
1	Ischemia 11/2007
1	Endotoxemia 11/2007
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/2006
1	Stroke (Strokes) 12/2006
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2006
1	Colitis 04/2006
1	Hepatitis 01/2005
1	Osteolysis 03/2002
1	Hypersensitivity (Allergy) 03/2002

Drug/Important Bio-Agent (IBA)

5	givinostatIBA 01/2021 - 03/2013
5	Histone Deacetylase InhibitorsIBA 01/2021 - 01/2005
4	givinostat hydrochlorideIBA 01/2019 - 01/2005
4	CytokinesIBA 08/2014 - 03/2002
3	Histone Deacetylases (Histone Deacetylase)IBA 01/2019 - 03/2002
2	Histones (Histone)IBA 12/2006 - 04/2006
1	Carrier Proteins (Binding Protein)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 12/2019
1	Histone Deacetylase 6IBA 12/2019
1	naringeninIBA 08/2014
1	Sericins (Sericin)IBA 08/2014
1	Hydroxyurea (Hydrea)FDA LinkGeneric 03/2013
1	Collagen Type II (Type II Collagen)IBA 05/2011
1	Peptides (Polypeptides)IBA 11/2007
1	lysylprolineIBA 11/2007
1	glycyl-(ethyl)lysyl-prolyl-arginineIBA 11/2007
1	Proteins (Proteins, Gene)FDA Link 12/2006
1	TransferasesIBA 12/2006
1	Hydroxamic Acids (Hydroxamic Acid)IBA 04/2006
1	Sulfonic AcidsIBA 04/2006
1	Valproic Acid (Depakote)FDA LinkGeneric 04/2006
1	Dextran SulfateIBA 04/2006
1	Concanavalin AIBA 01/2005
1	Immunoglobulin G (IgG)IBA 03/2002
1	SolutionsIBA 03/2002
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2002
1	AntibodiesIBA 03/2002

Therapy/Procedure

1	Organ Transplantation 12/2019
1	Microspheres (Microsphere) 08/2014
1	Therapeutics 12/2006
1	Oral Administration 04/2006